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KMID : 1035320170440010033
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Korean Society for Dental Materials
2017 Volume.44 No. 1 p.33 ~ p.41
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In vivo evaluation of infrared LASER mediated drug release of PLA-tetracycline complexes coated gold nanoparticle-titania nanotubes with mouse
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Mon Kyoung-Sook
Jeong Chan-Gwoun
Bae Ji-Myung
Oh Seung-Han
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Abstract
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In this study, we prepared PLA-tetracycline complexes coated gold nanoparticle-titania nanotubes and estimated their infrared LASER mediated drug release in the abdominal region of ICR mouse. The results of UV-Vis spectrophotometer showed the highest absorbance at the wavelength of 530 nm and 809 nm indicating the existence of gold nanoparticles. EDX analysis showed that the amounts of gold nanoparticle coated on titania nanotubes were approximately 3.62?36.5 wt%. In vivo test resulted that the tetracycline release value of experimental groups (6.5 ng/mL) was higher than that of control group (5.8 ng/mL) on the condition of 30 minutes of LASER irradiation. Therefore, it is expected that PLA-tetracycline complexes coated gold nanoparticle-titania nanotubes have the feasibility in the field of infrared remote controlled drug device and overcome the limitation of location and time of drug release in dental implant.
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KEYWORD
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PLA-tetracycline complexes, Gold nanoparticle(GNP), Titania nanotubes, Infrared LASER
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